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Since NASH is a largely asymptomatic disease, a drug with a burdensome side effect profile may not be acceptable

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In summary, the structure of the observation is given by where y denotes the logarithm of the data, x denotes the model prediction, s and b reflect scaling and offset parameters and the noise \(\epsilon \sim N(0, \sigma ^2)\) is a normally distributed random variable with standard deviation \(\sigma\)